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医学翻译样例二羟维生素D,EditSprings,艾德思

网络 | 2019/01/03 14:40:05  | 181 次浏览

 原文: 1,25-Dihydroxyvitamin D [1,25(OH)2D] is the meta- bolically active molecule responsible for most of the ac¬tions of vitamin D and is derived from 25(OH)D by 1a- hydroxylation primarily in the kidney. The main effect of 1,25(OH)2D is to increase calcium absorption from the gut. 1,25(OH)2D binds to the vitamin D receptor in the epithelial cells of the duodenum causing the synthesis of calcium binding proteins that regulate active intestinal calcium absorption. It also stimulates calcium reabsorption in the kidney. The production of 1,25(OH)2D is stimulated by PTH and its concentrations directly influenced by serum calcium and phosphate. In addition to regulating serum calcium uptake in the in¬testine and kidney, evidence from in vitro and animal stud¬ies suggest that 1,25(OH)2D may also regulate calcium resorption from bone by having direct effects on bone cells. There is, however, little information on the potential impact of serum 1,25(OH)2D on bone health including turnover. 译文: 1,25-二羟维生素D [1,25(OH)2D]是一种活性代谢分子,担负维生素D的大部分活性,主要在肾脏中通过对25(OH)D进行1a-羟基化生成.1,25(OH)2D的主要作用是增加肠道内钙吸收.1,25(OH)2D与十二指肠上皮细胞中的维生素D受体结合后引起钙结合蛋白的合成,钙结合蛋白能够调节肠道内活性钙吸收水平.钙结合蛋白也能刺激肾脏对钙的重吸收. PTH能够刺激1,25(OH)2D的生成,而PTH的浓度直接受到血清钙和磷的影响(15).1,25(OH)2D除调节肠道和肾脏对血清钙的摄取外,体外和动物研究结果显示,1,25(OH)2D能够通过对骨细胞产生直接效应来调节对骨钙的重吸收.但血清1,25(OH)2D对骨骼健康的潜在影响包括转换方面的研究较为缺乏.

 

 

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