赵华四川农业大学动物营养研究所研究员,EditSprings,艾德思



 

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赵 华 博士,四川农业大学动物营养研究所研究员,博士生导师,四川省科学与技术带头人后备人选.美国普渡大学访问学者.从事动物营养与分子生物学相关研究工作.先后主持或参研科研项目10余项,其中包括主持国家自然科学基金面上项目4项,主持和主研国家"863'项目子课题各一项.已在J Nutr, PLOS One,Enzyme and microbiolgy technology及动物营养学报等国内外知名刊物上发表科研文章90余篇,其中sci文章50余篇.申报国家发明专利4项,获授权专利2项,专利号:和ZL ..2012年获四川省科技进步二等奖1项(排名4).

研究方向: 饲料资源开发与利用/分子营养

一/学历和工作简历:

教育经历

2002/9 - 2006/12,重庆大学,生物医学工程,博士

1999/9 - 2002/7,四川农业大学,动物营养与饲料科学,硕士

1993/9 - 1997/7,西南农业大学,动物营养与饲料加工,学士

工作经历

2016/10-至今,四川农业大学,动物营养研究所,研究员

2009/12 - 2016/10,四川农业大学,动物营养研究所,副研究员

2013/09 - 2014/09,美国普渡大学,动物科学系,访问学者

2007/4 - 2010/1,四川农业大学,动物营养研究所,助理研究员

2005/11 - 2007/4,四川农业大学,动物营养研究所,助教

二/教学课程: 硕士研究生<饲料资源开发与利用>课程,本科生<饲料学>课程

三/指导研究生: 毕业硕士研究生6人,在读6人

四/当前主要研究工作:

1/国家自然科学基金面上项目"生长猪骨骼肌热应激损伤中硒蛋白表达调控及其抗应激机制分析'(No:31772643),2018-2021,主持;

2/国家自然科学基金面上项目"日粮硒缺乏致雏鸡胰腺萎缩差异基因表达分析及分子网络构建',2013-2016,主持;

3/国家自然科学基金面上项目"应用siRNA技术结合基因置换和超表达探讨猪selX基因生物学功能的研究',2011-2011,主持;

4/国家自然科学基金面上项目"微型猪近交系肥/瘦表型腺体组织硒蛋白基因差异表达分析',2009-2011,主持;

5/四川省教育厅重点项目"热应激对肠道IPEC-J2细胞硒蛋白基因表达的影响',2017-2019,主持;

6/国家863计划子课题"猪胰腺消化酶基因表达活性分析及转基因发酵生产',2008-2010,主持;

7/国家863计划子课题"抗菌肽基因表达活性分析及转基因发酵生产',2008-2010,第一主研;

8/四川农业大学双支计划;

9/企业合作项目.

五/代表性科研成果

Cao L, Tang JY, He AH, Jia G, Liu GM, Chen XL,Tian G, Cai JY, Shang HY, Zhao H *. SeleniumsupplementationalleviateHS-inducedIPEC-J2cellsinjuryvia regulation expression of severalselenoproteingenes. Under submission

Tang JY, He AH,Yan H, Jia G, Liu GM, Chen XL, Tian G,Cai JY, Shang HY, Zhao H *.2017.Damage to the myogenic differentiation of C2C12 Cells by heat stress is associated with up-regulation of several selenoproteins.submitted

Tang JY, He AH, Jia G, Liu GM, Chen XL, Cai JY, Shang HY, Liao JQ, Zhao H *.2017. Protective effect of selenoprotein X against oxidative stress-Induced cell apoptosis in human hepatocyte (LO2) cells via the p38 pathway. Bio Trac Elem Res.DOI: 10.1007/s12011-017-1025-z

Xu JY, Wang LQ, Tang JY, Liu GM, Chen XL, Cai JY, Shang HY, Zhao H *.2017. Pancreatic atrophy caused by dietary selenium deficiency induces hypoinsulinemic hyperglycemia via global down-regulation of selenoprotein encoding genes in broilers. PLoS ONE 12(8): e0182079.DOI: 10.1371/journal.pone.0182079

Tang JY, Huang XF, Li Q, Xu JY, Jia G, Liu GM, Chen XL, Shang HY, Cai JY, Zhao H *. 2017. Supranutritional dietary selenium depressed expression of selenoprotein genes in three immune organs of broiler. Animal Science Journal., 88:331-338. (sci,IF=)

Huang XF, Tang JY, Xu JY, Jia G, Liu GM, Chen XL, Shang HY, Cai JY, Zhao H *.2016. Supranutritional Dietary Selenium Induced Hyperinsulinmia and Dyslipidemia via Affected Expression of Selenoprotein Genes and Insulin Signal-related Genes in Broiler.Rsc Advances.6:84990-84998. (sci,IF=)

Tang JY, Cao L , Li Q, Xu JY, Jia G, Liu GM, Chen XL, Shang HY, Cai JY, Zhao H *.2016.Selenoprotein X gene knockdown aggravated H2O2-Induced apoptosis in liver LO2 cells. Bio Trac Elem Res.173:71-78.(sci,IF=)

Cao L, Tang JY, Li Q, Xu JY, Jia G, Liu GM, Chen XL, Shang HY, Cai JY, Zhao H *.2016.Expression of selenoprotein genes is affected by Heat stress in IPEC-J2 Cells. Bio Trac Elem Res. 172:354-360.(sci,IF=)

Zhao H *, Li K, Tang JY,Zhou JC, Wang KN, Xia XJ,Lei XG.2015 Expressions of selenoprotein genes is affected by obesity pigs fed a high-fat diet.J Nutr.145(7):1394-401. (sci,IF=)

Zhao H *, Tang JY,Cao L, Jia G, Long DB, Liu GM, Chen XL,Cai JY,Shang HY.2015.Characterization of bioactive recombinant antimicrobial peptide Parasin I fused with human lysozyme expressed in the yeast pichia pastoris system.Enzyme and microbiolgy technology.77:61-67. (sci,IF=)

Zhao H *, Tang JY, Xu JY, Cao L, Jia G, Long DB, Liu GM, Chen XL, Wang KN.2015.Selenoprotein Genes exhibited differential Expression pattern between hepatoma HepG2 cell and normal hepatocytes LO2 cell line. Bio Trac Elem Res. 167:236–241 (sci,FI=)

Zhao H *, Chen D, Tang JY, Jia G, Long DB, Liu GM, Chen XL, Shang HY. 2014. Partial optimization of the 5-terminal codon increased a recombination porcine pancreatic lipase (opPPL) expression in Pichia pastoris. Plos ONE. 9(12):e114385. (sci,IF=)

Sun LH, Li JG, Zhao H , Shi J, Huang JQ, Wang KN, Xia XJ, Li L and Lei XG.2013.Porcine Serum Can Be Biofortified with Selenium to Inhibit Proliferation of Three Types of Human Cancer Cells. J Nutr,143:1115-1122. (sci,IF=)

Liu Y, Zhao H *, Zhang QS, Tang JY, Li K, Xia XJ, Wang KN, Li K, and Lei XG.2012. Prolonged dietary Se deficiency or excess does not globally affect selenoprotein gene expression and/or protein production in various tissues of pigs.J.Nutr,142: 1410-1416. (sci,IF=)

Zeng MS, Li X, Liu Y, Zhao H , Zhou JC, Li K, Huang JQ, Sun LH, Tang JY, Xia XJ, Wang KN, Lei XG.2012. A high-selenium diet induced insulin resistance in gestating rats and their offspring. Free Radical Biology & Medicine, 52:1335-1342. (sci,IF=)

Huang JQ, Li DL, Zhao H , Sun LH, Xia XJ, Wang KN, Luo X, Lei XG.. 2011.The selenium deficiency disease exudative diathesis in chicks is associated with downregulation of seven common selenoprotein genes in liver and muscle. J Nutr,141:1605-10. (sci,IF=)

Li K, Zhao H ,Zhou JC,Tang JY,Lei XG,Wang KN.2011.Differentially expressed genes in subcutaneous tissues in an obese pig models induced by a high-fat diets.Journal of animal and veterinary advances.10(14):1804-1810. (sci)

Li JG, Zhou JC, Zhao H , Xia, XJ , Lei XG and Wang KN. 2011. Enhanced water-holding capacity of meat was associated with increased Sepw1 gene expression in pigs fed selenium-enriched yeast.Meat Science ,87:95-100. (sci,IF=)

Zhou JC, Zhao H, Li JG, Xia XJ, Wang KN, Zhang YJ, Liu Y, Zhao Y, and Lei XG. 2009.Selenoprotein gene expression in thyroid and pituitary of young pigs is not affected by dietary selenium deficiency or excess. J. Nutr, 139(6):1061-1066.(sci,IF=)

汤加勇, 赵华 *,贾刚,刘光芒,陈小玲,蔡景义,吴彩梅. 2016. Selx基因沉默及H2O2应激对LO2细胞中硒蛋白基因表达的影响.动物营养学报.28(8):2431-2438.

汤加勇, 赵华 *,何爱华,周继昌,贾刚,刘光芒,陈小玲,蔡景义.2016.猪硒蛋白P基因克隆/鉴定及组织mRNA相对表达量分析. 动物营养学报, 28(3): 858-863.

赵华 *,汤小朋,汤加勇,曹蕾,王雪涛,贾刚,刘光芒,陈小玲,王康宁.2016.复合生态菌固态发酵木薯渣工艺参数优化及混菌发酵对木薯渣营养品质的影响.中国畜牧杂志.52(5):55-59

赵华 *,王雪涛,汤加勇,汤小朋,贾 刚,刘光芒,陈小玲,龙定彪, 王康宁.2015.复合益生菌固态发酵改善甘薯渣营养价值的研究.动物营养学报, 27(4):1191-1198.

赵华 *,王雪涛,汤加勇,汤小朋,贾 刚,刘光芒,陈小玲,龙定彪, 王康宁.2015. 黑曲霉固态发酵甘薯渣条件优化及发酵对甘薯渣营养品质的影响.四川农业大学学报.33(1):51-56.

赵华 *,汤加勇,曹蕾,周继昌,贾刚,刘光芒,陈小玲,王康宁.2015.硒蛋白selX基因克隆/定点突变/原核表达及多克隆抗体制备.动物营养学报.27(5):1485-1491.

汤小朋, 赵华 *,汤加勇,王雪涛,贾　刚,刘光芒,陈小玲,龙定彪.2014. 黑曲霉固态发酵改善木薯渣品质的研究. 动物营养学报, 26(7):2026-2034.

赵华 *,张艳艳,汤加勇,李珂,周继昌,王康宁.2012.重组鲢鱼抗菌肽parasinI原核表达/纯化与抗菌活性. 动物营养学报, 24(9): 1731-1736.

专利 :

1.申请获得国家发明专利"一种酸性海藻糖酶及其制备技术',专利号:,专利公布号:CN1793348.第二申请人.

2.申请获得国家发明专利"一种利用混菌发酵技术改善木薯渣品质的方式',专利号:.第一申请人.

3.申请国家发明专利"一种利用毕赤酵母高效分泌表达重组猪胰腺脂肪酶PPL的方式 ',专利申请号:.第一申请人.

4.申请国家发明专利"一种利用毕赤酵母表达人溶菌酶-抗菌肽ParasinI融合蛋白的方式',专利申请号:.第一申请人.

获奖 :

2012获得四川省科技进步奖二等奖,排名第4,获奖项目"猪鸡饲料净能评定及需要量研究与产业化应用'

六/奖励和荣誉 :

四川省科学与技术带头人后备人选

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