SCI写作常用经典句式（下）EditSprings艾德思

接上篇

与…一致,相符

1．Consistent with this notion, recent studies have shown that IL-7 is essential for the survival and basal homeostatic turnover of Ag-specific CD4+memory cells.

2. Similarly broad expression of IL-2 and IL-15 receptors do not coincide well with the highly restricted roles that IL-2 and IL-15 appear to play in thymic development.
3．The distinct functions of IL-2, IL-15, and IL-7 signals in naive T cell homeostasis correspond well with the expression patterns of the various receptor chains.

4. A comparison of wild-type and CD25?/? CD8+ T cells side by side in a mixed radiation chimera following LCMV or Listeria infection revealed that the knockout cells could divide as fast as wild-type cells and accumulate to large numbers of effectors (54), in line with previous findings.

5 ． These experiments are also in agreement with physiological studies showing that T cells activated by soluble peptide in vivo are not committed to tolerance after 3 d

6. Results presented in this work do not contradict this hypothesis, but suggest that in addition to its function as a “T cell graveyard,” the liver may play a role in primary activation of CD81 T cells specific for Ags presented within the liver, including peptides delivered by the i.v. route.

被迫

1．These effector T cells undergo a dramatic contraction in numbers after antigen clearance, with 90 – 95% succumbing to apoptosis within weeks.

与…相反,相反地…

1.In contrast to CD8 memory T cells, CD4 memory T cells may not require the signals through common cytokine receptor chain.
2.By contrast, IL-2 signaling may play a major role in the differentiation of regulatory T cells

3.Contrary to T-cell recognition of peptides processed and presented on MHC molecules by DC, immunoglobulin receptors on B cells recognize intact protein antigens in their native state.

参与了

1.The polycomb group (PcG) gene Bmi1 has recently been implicated in the maintenance of hematopoietic…
2.an intrinsic histone H3-K27 methyltransferase activity, which implicates a likely mechanism for PcG-mediated gene silencing.

本课题研究了…在…的作用

1. We herein investigated the role of Bmi1 in the generation and maintenance of memory CD4 + Th1/Th2 cells.

研究(清楚)表明…

1. Our results indicate that Bmi1 controls memory CD4 T cell survival and function through the

direct repression of the Noxa gene.

2.However, follow-up studies have not revealed an obvious defect in thymic selection

3.Multiple in vitro studies demonstrate that T cell activation depends on the presence of IL-2.

4.The results conclusively demonstrated that IL-2 was dispensable

as a growth factor for antiviral CD8 T cells in secondary lymphoid tissues

在…方面缺乏让人信服的证据

1．Compelling evidence in this regard is currently lacking.

与…相比

1. Although the expression levels of IL-7R _ and IL-2R _ were slightly lower on Bmi1 _ / _ memory Th2 cells as compared with wild-type cells.

静脉过继转移到…

1. (A andBmi1 +/+ , Bmi1 +/ _ , or Bmi1 _ / _ effector Th2 (A) or Th1 (cells with DO11.10 Tg background were intravenously transferred into BALB/c nu/nu mice.

大量的证据表明…

1．Hence, despite a plethora of in vitro evidence showing that IL-2 was critical for supporting T cell activation, the dominant physiological function of IL-2 signals in vivo is to restrain T cell activation and prevent autoimmunity.

A 对 B 很重要

1．IL-2 is clearly essential/critical for Treg differentiation.

2 ． The non-homologous DNA end-joining (NHEJ) pathway has an essential role in joining double-strand breaks (DSBs) generated by the RAG proteins during V(D)J recombination;

3.CD4+ T cells play an essential role in promoting the initial expansion of CD8+ T cells responding to initial antigen challenge when antigen comes from a relatively noninflammatory immunogen.
4.One attractive possibility is that the subset of endogenously activated CD4+ T cells that express low levels of CD25 and make numerous cytokines are key to maintaining CD8+ memory T cells. 5．DCs are central to the priming of both primary and secondary CD8+ T cell responses.

6.Our results therefore suggest that TLRs can play a crucial role in shaping the development of the adaptive immune system.

引出…问题

1．These results raise the question of the extent to which the suppressive actions of TGF-β and IL-27 are mediated by their capacity to promote IL-10 production by other cells.

2. The observation that CD8+ T cell differentiation is programmed after a relatively short exposure to antigen has brought into question the nature of CD8+ T cell–DC interactions in vivo. 3．The expression of AID in developing B cells in both mutant and normal mice (Maoet al., 2004) raises questions regarding the mechanism of AID induction at these early stages of B cell development.

不奇怪地，可以预期地

1．Not unexpectedly, the newest ‘lineage’ of helper T cells, TH-17 cells, also received a great deal of attention at the Ringberg meeting.

2. As expected, RAG-2 expression is detected only in pre-B and immature B cells, validating our cell-purification procedure.

面对严峻的挑战

1．The question then became how to tackle such a daunting challenge.

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