艾德思：让动脉和心脏创口闭合的光敏胶粘剂自然



让动脉和心脏创口闭合的光敏胶粘剂 | <自然-通讯>

文章标题:A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds

期刊: Nature Communications

作者:Yi Hong, Feifei Zhou, Yujie Hua, Xianzhu Zhang, Chengyao Ni, Dihao Pan, Yiqing Zhang, Deming Jiang, Long Yang, Qiuning Lin, Yiwei Zou, Dongsheng Yu, David E. Arnot, Xiaohui Zou, Linyong Zhu, Shufang Zhang, Hongwei Ouyang

发表时间:2019/05/14

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<自然-通讯>本周发表的一篇文章 A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds 描述了一种 可以让动脉和心脏创口闭合的光敏胶粘剂 .这种"生物胶'的效果已经在猪模型中得到了证实,有望将来应用到外科手术中.不过,仍需在后续试验中开展进一步研究(包括涉及人体的研究),确认这种胶的使用安全性.

图1: 实验水凝胶的化学结构 图源:Hong等

创伤后或手术中出现的无法控制的出血是造成死亡的主要原因,如果不进行缝合(缝线),伤口将难以闭合. 采用胶粘剂的方式则要求胶粘剂不仅要对湿组织有较强的粘附力,其强度也要能抵抗高血压和心脏跳动时的血液流动. 然而,满足以上要求的无毒材料非常少.

图2:该凝胶在猪颈动脉损伤模型中的止血作用 图源:Hong等

浙江大学医学院的欧阳宏伟和同事设计了一种模仿细胞外基质(即由蛋白质等分子组成的网络)构成的凝胶,能在紫外光照射下迅速固化.在实验室开展的初步动物实验中, 作者的系统能够使猪肝上的创口闭合 .随后,作者又通过一组猪外科手术表明, 这种水凝胶也能让猪心脏的创口在无需缝合的情况下闭合. 术后,研究小组对三只猪进行了为期两周的恢复期监测,并未发现手术导致的任何异常.

摘要:Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo-reactive adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60–160 mm Hg). Most importantly, the hydrogel can stop high-pressure bleeding from pig carotid arteries with 4` 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant.

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(来源:科学网)

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